Van,
I'm going to answer your last question first. That would be a resounding YES, ALWAYS!!!
The integrated braking system exists only on the AN400's, the AN650 has discrete brakes; left grip rear brake, right grip front brake.
The 400's integrated brake system is different. The left grip controls the upper pistons on the front brake, & the rear brake simultaneously. It delivers biased braking, utilizing about 70% of the braking force to the rear & 30% to the front brakes. That is the left brake lever. (I stress that as it took me awhile to pound that through my own thick skull)
The right brake lever controls the larger surface area, lower pistons on the front brake only, providing 100% of the braking power of the right grip to the front wheel.
I have never ridden a bike with this setup, so I cannot give you first hand experience, but from what I have read here, the more experienced riders prefer the discrete braking of the 650. Thier thinking is that it gives them greater control of the braking ability of the bike. They may be right, I, as I said, have little experience in this area.
The linked braking (another term meaning the same as "Integrated" braking) is thought to be beneficial for the less experienced rider, who, as a rule, is prone to over-utilize the rear brake. This system appears to ameliorate that condition somewhat. Most newbies are scared to death of too much front brake, causing the nose to dive & possibly leading to loss of control.
Locking up the rear wheel in a panic stop, isn't usually too tough to manage as long as you are continuing in a straight line, & not in the middle of a turn, where the rear of the bike will want to come around on you, not unlike deliberately locking the brakes on your bicycle to come to a "cool" sliding stop in front of your friends. The downside of that scenario is that on a bicycle, your leg(s) can handle the weight & inertia without too much trouble, when attempting that on a 600 lb bike, it's a whole other ballgame, usually resulting in catastrophe.
Locking up the front wheel is not normaly a good thing, it usually (if not ALWAYS) results in complete loss of directional control, & can be catastrophic if you let off the front brake in the midst of a slide. The wheel can begin turning again, regain traction & abruptly change your direction of travel before you realize it & can react to the new situation, among other nasty things.
This is the meat of my reading on this subject. If I am incorrect in my assesment(s), somebody please correct me. If I have left anything out, please feel free to stick in your .02 worth, by all means.
I hope this answers your question(s), or if not, then at least makes it a bit clearer for you, Van.
I'm tryin'! (I just hope I'm not tryin' your patience!)