I own a 400 and regularly get over 60 MPG, sometimes over 70 MPG, with a big Givi screen and a 320-pound rider. The key is all in how you ride, and it's all obvious stuff. Try and time lights so that you don't have to stop- accelerating away from lights costs lots of gas. Accelerate slowly, as pointed out above. Try riding at 5-10 MPH below the speed limit. Avoid high-speed Interstate highway runs. Travel when traffic is very light when possible, so that you can set the pace of your choosing and remain there.
And, of course, follow the above advice ONLY when it's safe to do so. Flesh and blood are still slightly more costly than gas, the last I heard. (Who knows by Labor Day?)